Cannabis Sativa L. contains 113 naturally occurring, active compounds called cannabinoids. CBD is most important non-psychotropic cannabinoids and the second most abundant cannabinoid in cannabis plant, which positively interacts with our health system. Unlike the commonly known THC, it does not cause a high. Due to clinical researches, CBD regulates the body’s homeostasis, general state of balance, impacting such functions as mood, sleep, appetite, hormone regulation, and pain.Through all this discoveries the great news for us all is that  there is now a way to reap the plant’s medicinal benefits without a need for the “high”of THC.

CBD was first isolated in the 1930s and 1940s, but it was not until 1960s that its structure was fully analyzed by Professor Raphael Mechoulam and his team of researchers in Israel. Recent research and studies have concluded that CBD is beneficial for those suffering from various ailments and many scientists and health practitioners agree that CBD is definitely the most important cannabinoid ever identified


CBD  interacts with your body through the endocannabinoid system (ECS). This vast system looks after your body’s general state of balance (otherwise known as homeostasis). It’s made up of chemical compounds and receptors that all act to maintain your mind and body’s balance.This means that when used, CBD helps functions such as appetite, mood, immune response, pain and sleep by correcting anything that’s slightly out of alignment in order to keep us nice and ‘level’.

All cannabinoids, including CBD, act on receptors found in all mammals. These receptors are part of the endocannabinoid system. Clinical trials are currently looking into the effect of CBD on the body. So far the findings that we can legally share with you are the discovery of 2 main receptors in our bodies:

CB1 receptors: Mostly found in the brain, lungs, blood vessels, muscles, digestive tract, reproductive organs and central nervous system.
CB2 receptors: Mostly found around organs, liver, pancreas, brainstem and also the immune system


CBD might seem to be something new for most. However, humans have already been using this wonder extract for thousands of years. Early civilizations used hemp, a plant naturally rich in CBD, to treat various illnesses. CBD itself however was only identified in 1930s and 1940s. Thorough research and studies about this compound have not commenced until the 1960s.

CBD is mostly responsible for most of the health benefits of the cannabis plant. It helps the body work to its optimal potential by feeding the body’s endocannabinoid system. A healthy endocannabinoid system promotes balance within the cellular mechanisms of the body. This helps relieve a myriad of ailments and illnesses many people suffer from.First things first: legalisation. Cannabis is completely legal for anyone over 21 in eight states and medically legal in 29 in the USA. Countries like Canada, Uruguay, and Israel have also decriminalised the plant, illustrating how people and government the world over are starting to embrace cannabis’s diverse qualities and benefits.

There’s also a difference in the various types of cannabis. Certain cannabis strains, notably CBD-dominant varieties, don’t produce the euphoric or psychoactive effects (also known as a high) usually associated with consuming cannabis. Instead, CBD-dominant strains—and products derived from them—only provide medical relief, which is great news for those looking for natural solutions to their ailments.Until recently, the benefits of CBD have gone largely undiscussed. In 2013, though, CBD became a hot topic in the Unites States after a CNN documentary told the story of a six-year-old girl, Charlotte Figi, who suffered from a severe, intractable form of epilepsy called Dravet syndrome. The documentary showed how strains of CBD-dominant cannabis helped to dramatically reduce her seizures, from 300 a week to just a couple a month without producing a “head high.”

But CBD can be used for more than just serious cases of epilepsy. Because it doesn’t get users “buzzed,” it’s a natural alternative for individuals interested in learning about the medicinal benefits of cannabis who don’t want a “mind altering” experience.Which led to active  FDA Approved products such as Marinol capsules (and generics) and Syndros oral solution. CBD is the active ingredient in the approved drug product, Epidiolex.[1]Because of the role the ECS plays in pain perception and inflammation, CBD can be used for many different types of pain, including: chronic pain, nerve pain, joint pain, migraines, even fibromyalgia. In fact, according to a recent HelloMD survey, 42 percent of CBD users said they stopped taking traditional medications—think over-the-counter (OTC) painkillers such as Tylenol and prescription meds like Vicodin—in favor of CBD. Therefore, CBD could be crucial in helping our country fight a devastating opioid epidemic, as well as helping to avoid other health issues associated with taking too many OTC NSAIDs.


Learn the Types of CBD Products

Before you start taking CBD, please read about drug interactions
It is important to note that even something as benign as grapefruit juice can cause the same CYP450 enzyme inhibitory action as CBD.

The most important things to do before taking CBD (or any other herbal product) are research any possible drug interactions and talk with your physician to address any additional questions regarding CBD drug interactions or overdose concerns. You and your doctor together will always know best!

Understand How Your Genetics Impact CBD Dosing
As if you didn’t have enough factors to consider when deciding your ideal CBD oil dosage, now you have to think about how your own genetics can impact this amount.

Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.

Here are some other cellular-level factors that can affect how CBD is absorbed in your body:

Various substances can profoundly affect CB1 receptors. Certain lifestyle choices can impact how your body metabolizes CBD.

What does this mean? Well, for example, THC increases the activity of CB1 receptors [1], while ethanol (alcohol) increases its expression [2]. So, theoretically, smoking cannabis and drinking alcohol may increase the effects of CBD.

Morphine and epinephrine decrease the activity of the CB1 receptor [3],[4].

What does this mean? It may mean those currently using opiates could, with approval and guidance from their physician, find CBD useful in decreasing opiate use .

Exercise and nicotine both increase anandamide levels (while similar to THC – this is a cannabinoid that we naturally synthesize in our brains) which is a natural CB1 receptor activator [5].

What does this mean? Being active, as well as ingesting nicotine (while the latter is not recommended), might increase the effects of CBD.

DHA (an omega-3 fatty acid) increases CB1 receptors [6].

What does this mean? Theoretically, those eating a diet rich in fatty fish would naturally need to use less CBD oil.

Prolonged elevated glucocorticoids (such as cortisol) reduce CB1 receptor density [7].

What does this mean? Those under high levels of chronic stress would potentially need higher CBD oil dosage to achieve the same effects achieved by people who are not chronically stressed.

We are only beginning to understand genetics, and as such it’s a good idea to take anything related to this emerging science with a grain of salt. As with any natural substance, consult with your physician about any questions and/or concerns you may have regarding CBD and how to use CBD oil.

Rest Easy Knowing CBD Oil Is Not Physically Addictive
People often ask us, “Can I get addicted to CBD oil?” This is a tricky question, and the answer ultimately depends on your school of thought.

Based strictly on chemistry, the answer is no. Cannabidiol is not physically addictive in the same way substances like heroin, cocaine, alcohol, opiates, benzodiazepines, and related substances can be. Further, CBD cannot produce any physical withdrawal symptoms in and of itself upon cessation of use.

(Interestingly, CBD is currently undergoing study for its ability to minimize withdrawal from drugs with severe cessation symptoms, like opiates.)

However, human beings can get addicted to just about anything that isn’t chemically addicting: exercise, music, sex,coffe ,tea and food are great examples, not to mention alcohol and cigarettes.

Those who take CBD daily to relieve symptoms of chronic illness and other severe conditions may find that their unpleasant sensations return shortly after they miss a dose. This is no different than one’s headache returning once the effects of ibuprofen wear off.

However, because CBD can alter the levels of essential liver enzymes, it is crucial to do your research, talk to your physician, and figure out the best way to take CBD oil for your specific situation. Information and education will be your allies in your quest for healing.


Proper knowledge about CBD will greatly enhance your understanding why CBD oil is the future of modern medicine. That is why at LivePlug, we encourage you to research and become educated about the potential health benefits of this wonder extract.  As you learn more about CBD, you will see many of its highly effective medical applications for the body and mind.